Meanings of become maladaptive in English

At the early phases of cardiac diseases, inducible NOS reinforces these effects, which may become maladaptive as disease progresses.

Because of this, it is important to point out the potential survival function of these conditions (even though they have become maladaptive).

This reorganization of host priorities represents a beneficial response that is normally adaptive but may become maladaptive when the profile of microglia is compromised.