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1 Gene expression profiling revealed that TRPM1 is highly enriched in ON- bipolar cells .
2 We find that P-type bipolar cells outnumber M-type bipolar cells at all eccentricities.
3 Both ON and OFF bipolar cells receive axonal veto synapses.
4 Photoreceptors and bipolar cells did not express any of these proteins at their axon terminals.
5 RS1 is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex.
6 Objective: This in vitro investigation examines the response of retinal bipolar cells to extracellular electrical stimulation.
7 However, how this process is regulated and coordinated with differentiation of photoreceptors and bipolar cells remains unknown.
8 Further, bipolar cells show extensive inputs and outputs along their axons, similar to multistratified nonmammalian bipolar cells .
9 The kinetics of simulated light responses from individual rod bipolar cells were recorded by whole-cell patch-clamp electrophysiology.
10 Some bipolar cells were also weakly immunostained.
11 The latter bipolar cells were found to exist as a large cell population comparable to rod bipolar cells .
12 Electroretinograms revealed that the electrophysiological function of retinal bipolar cells was impaired as a result of Otx2 ablation.
13 These data suggest that Otx2 plays a functional role in the maturation of retinal photoreceptor and bipolar cells .
14 RS1 antibodies also labeled retinal bipolar cells of photoreceptorless mice and retinal bipolar cells grown in cell culture.
15 Although these newly produced neurons were limited in number, retinoic acid treatment promoted the number of regenerated bipolar cells .
16 These results point to a possibly different regulation of the mGluR6 signaling cascade between rod and cone ON- bipolar cells .
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