1
In particular, botulinum neurotoxins have been demonstrated to potentially benefit a range of chronic pain syndromes.
2
This opens the possibility of using EGA as a lead compound to develop novel inhibitors of botulinum neurotoxins.
3
SNARE proteins are specific substrates of botulinum neurotoxins (BoNT) which are now widely used for therapeutic and cosmetic purposes.
4
Clostridium botulinum neurotoxins are potently toxic proteins of 150 kDa with specific endopeptidase activity for SNARE proteins involved in vesicle docking and release.
5
This review will consider the evidence for the analgesic properties of the botulinum neurotoxins and their suitability as the basis for novel therapeutic proteins.
6
Botulinum neurotoxins are one of the most potent toxins found in nature, with broad medical applications from cosmetics to the treatment of various neuropathies.