Meanings of bulbar onset in English

Conclusions: Results highlight a significant vulnerability of ALS female patients to develop cognitive dysfunctions peculiar to the disease, independently of bulbar onset.

In this population-based series, progressive muscle weakness was the most common presenting sign; bulbar onset was associated with advanced age and female sex.

ALS cases with C9ORF72 expansions frequently showed a bulbar onset of disease (57 %) and more rapid disease progression to death compared to non-expansion cases.