Despite the paucity of human testing, some people already practice caloric restriction.

The life-prolonging effects of caloric restriction are likely related to decreasing IGF-1 levels.

Interestingly, the caloric restriction regimen also leads to phospho-activation of AMPK in muscle.

An additional 6 wk of caloric restriction maintained the improvement in glucose metabolism.

There's just one way to lose weight: sustained caloric restriction and increased aerobic exercise.

We report here that lifelong caloric restriction completely prevents the age-related deficit in LTP.

Moderate dietary or caloric restriction (DR) modulates animal physiology in a beneficial fashion.

Enticing research also comes from studies of caloric restriction.

Every major pharmaceutical company is conducting research on the handful of genes activated by caloric restriction.

One paradigm, lifelong caloric restriction, has been reported to reduce some of the effects of aging.

These modifications mimic the effects of caloric restriction, which is associated with the activation of autophagy.

Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents.

In animal models, caloric restriction (CR) suppresses these diseases as well as chemical-induced tissue damage.

PMID: 12655029 Moderate dietary or caloric restriction (DR) modulates animal physiology in a beneficial fashion.

Thousands of people already practice caloric restriction, which requires incredible discipline and may cause unwanted metabolic changes.

So I'm working with some other scientists to look at, how does this work with caloric restriction?