Meanings of canonical wnt in English

Aberrant stimulation of the canonical Wnt pathway induces mammary tumorigenesis in mice.

These data implicate an obligatory role for canonical Wnt signaling in rugae development.

Previous studies have associated activation of canonical Wnt signaling in osteoblasts with elevated bone formation.

The role of another embryonic signaling pathway, namely the canonical Wnt cascade, is still controversial.

We and others demonstrated that R-spondins can activate canonical Wnt signaling and beta-catenin-dependent gene expression.

MeCP2 and DNA methylation may provide molecular mechanisms for canonical Wnt pathway activation in RA.

This study demonstrates that canonical Wnt signaling inhibits HIV and significantly correlates with HIV controller status.

During kidney development, canonical Wnt signaling activates differentiation, while the transcription factor Six2 maintains the progenitor pool.

MiR-152 and DNA methylation may provide molecular mechanisms for the activation of canonical Wnt pathway in RA.

We created a transgenic mouse that conditionally expressed the canonical Wnt ligand in the developing kidney, Wnt9b.

Taken together, our findings provide a novel promising chemotype for CRC therapeutics development targeting the canonical Wnt signaling.

Thus, Wtx is a regulator of MPC commitment and differentiation with stage-specific functions in inhibiting canonical Wnt signaling.

Canonical Wnt signaling regulates many aspects of cellular physiology and tissue homeostasis during development and in adult organisms.

Tumors lacking this tumor suppressor gene exhibited a mesenchymal phenotype characterized by inhibition of the canonical Wnt pathway.

Antagonizing canonical Wnt activity in CD8+ T cell CM resulted in increased HIV transcription in infected cells.

Inhibition of the beta-catenin or canonical Wnt pathway resulted in similar down-regulation of both ABC transporter expression and function.