1
However, its cellular target and mechanism of action are poorly understood.
2
We demonstrated that T reg cells are an important cellular target of the combination therapy.
3
Either growth factor-toxin fusions or antibody-toxin fusions can be chosen, depending on the cellular target.
4
It is generally believed that Tat has one or more transcription factors as its cellular target.
5
This method of derivatization will be valuable for cellular target identification, mechanism of action studies, and drug development efforts.
6
XopJ is a T3E protein from Xcv that interferes with plant immune responses; however, its host cellular target is unknown.
7
To identify the relevant targets underlying the specific vulnerability toward tozasertib, we determined its cellular target profile by chemical proteomics.
8
However, for many of these hits, the cellular target has not yet been identified, thus preventing further target-based optimization of the compounds.
9
With its cellular target known we sought to optimize the biochemical and cellular Nampt activity of 1 as well as its cytotoxicity.
10
These cells are abundant in demyelinated regions of patients with multiple sclerosis, yet fail to differentiate, thereby representing a cellular target for pharmacological intervention.
11
In studies determining the specific ER subtype and cellular target involved, EDC decreased infarct size and improved functional recovery in mice lacking ERa in cardiomyocytes.
12
Here we show that the T-cell is a critical cellular target of glucocorticoid receptor signaling, as immune activation in these mice resulted in significant mortality.
13
The extent of DNA breakage correlated with cell killing, supporting previous suggestions that DNA is the crucial cellular target of H2O2 cytotoxicity.
14
These results further indicate a role of MMP-3 in the demise of DArgic neurons and suggest MMP-3 as a candidate cellular target for neuroprotective therapy.
15
The mechanisms of action and cellular targets for Treg-mediated suppression remain controversial.
16
The aim of this study was to identify specific cellular targets of UDCA.
