Meanings of chemical inhibition in English

Kinase targets were also examined via chemical inhibition using a panel of kinase inhibitors.

Both a mutational approach and chemical inhibition were utilized to address how DNA-PK affects HR.

The decreased anti-tumor effect of sorafenib was rescued by chemical inhibition of ERK and AKT.

However, p53 degradation was not mediated via autophagy as shown by chemical inhibition and genetic abrogation of autophagy.

Inversely, migration was reduced by knockdown of SUV39H1 or chemical inhibition by chaetocin.

We found that chemical inhibition of PERK in human iPSC-derived neurons also increased neuronal cell death in response to ER stress.

Although we previously reported that receptor inhibition using siRNA or chemical inhibition obliterates the viability of melanoma cells, the mechanism was unclear.

In these cells, RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and cell death in vitro and in xenograft mouse models.

Suppression of tankyrase activity using knockdown or chemical inhibition causes loss of nuclear β-catenin and global reductions in transcription and histone H3 acetylation.

Haplodeficiency and chemical inhibition of Nampt cause defects in NAD biosynthesis and glucose-stimulated insulin secretion in pancreatic islets in vivo and in vitro.

We found that chemical inhibition of the activity of the phosphatase PP1 reduced FcγRI inside-out signaling, although the phosphorylation of FcγRI itself was unaffected.

Such a chemical inhibition of DNA-binding of proteins can be used to modulate processes such as replication, transcription, DNA repair and maintenance of epigenetic states.

These defects can be alleviated in HMMR-silenced cells with chemical inhibition of Eg5 but not through the silencing of Kif15.

CSN5-depleted cells exhibited enhanced activation of the PI3 kinase-Akt pathway, and chemical inhibition of this pathway reduced the level of senescence.

RNAi-mediated knockdown and chemical inhibition of the WEE1 kinase with a specific inhibitor, MK-1775, had a significant effect on both viability and apoptosis.

Remarkably, Salmonella-induced NLRC4 inflammasome activation was not affected by either chemical inhibition or genetic ablation of genes associated with PGE2 biosynthesis and signaling.