Background: Pre-emptive pregabalin might be beneficial to the patients undergoing laparoscopic cholecystectomy.

Conclusion: No differences were noted in all-cause costs attributable to pregabalin or duloxetine.

In addition, the administration of either combination improved motor incoordination induced by pregabalin.

Multimodal therapy may improve the motor side effect profile of pregabalin.

Blood samples were collected to report pregabalin exposure and to assess renal function.