This putative virus also was found to inhibit the proliferative response of certain clonedT cells to IL-2 and Ag.
2
The availability of clonedT cell lines that retain specific biologic function offers unique opportunities to characterize cell surface proteins and cell-cell interactions.
3
The role of IL 4 in the putatively IL 2-independent growth of certain clonedT helper cells is unclear.
4
These antibodies influence the specific immunological functions of the clonedT cells, suggesting that these antibodies react with the T cell receptor for antigen.
5
Moreover, maintenance cultures of several distinct subsets of clonedT cells apparently contaminated with this putative viral agent contained poorly growing cells and erythrocyte aggregates.
6
We have used the receptor on a clonedT cell line called D10.G4.1 (D10) to perform a structure-function analysis of this interaction.