Meanings of critical bottleneck in English

Poor retention of transplanted cells is the critical bottleneck of heart regeneration.

However, existing PU classification methods typically require an accurate estimate of the class-prior probability, a critical bottleneck particularly for high-dimensional data.

SCD1 is found upregulated upon renal cell transformation indicating that its activity, while not impacting proliferation, represents a critical bottleneck for tumourigenesis.

A critical bottleneck for temporal and regional sweat analysis is achieving uniform, high-throughput fabrication of sweat sensor components, including microfluidic chip and sensing electrodes.