Meanings of cyclin-dependent kinase in English

Purpose: Flavopiridol is the first cyclin-dependent kinase inhibitor to enter clinical trials.

The results implicate a putative cyclin-dependent kinase in the control of development.

The other three mutants caused phenotypes dependent on the particular cyclin-dependent kinase.

Cdc2 is the cyclin-dependent kinase that controls entry of cells into mitosis.

D-type cyclin-dependent kinase activities have not so far been detected in mammalian cells.

A major determinant of Acm1 stability is phosphorylation at consensus cyclin-dependent kinase sites.

Finally, the effects of cyclin-dependent kinase inhibitors on dihydrofolate reductase gene expression were evaluated.

The expression of cyclin-dependent kinase inhibitor p21 is dramatically increased in the mutant embryos.

CF neutrophils formed more NETs and this was reversed by cyclin-dependent kinase inhibitor exposure.

Purpose: Flavopiridol is a cyclin-dependent kinase inhibitor that prevents cell cycle progression and tumor growth.

Interestingly, this response was self-limited at later developmental time points by an upregulation of the cyclin-dependent kinase inhibitor p21.

Despite its partial structural similarity with the cyclins, p25 displays an unprecedented mechanism for the regulation of a cyclin-dependent kinase.

The expression of the transcription factor Sp1, a retinoblastoma-interacting protein, was also enhanced by all the cyclin-dependent kinase inhibitors tested.

These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.

Ibrance works by blocking two enzymes, cyclin-dependent kinase 4 and 6, that are involved in cell growth.

Treatment with the cyclin-dependent kinase inhibitor SCH727965 alone or in combination is a highly promising novel experimental therapeutic strategy against pancreatic cancer.