Meanings of define a novel in English

Mutations within a highly conserved region define a novel class of transformation-defective mutants.

These results define a novel translational regulatory function for the SV40 large-T antigen.

These results define a novel redox-based mechanism to propagate Fas-dependent apoptosis.

They thus define a novel paradigm for Golgi genesis and inheritance.

These results define a novel mechanism of protein kinase C autoregulation at a transcriptional level.

In this report, we define a novel role for apoE in modulating adipocyte lipid metabolism.

Our results define a novel pathway regulating NFkB activation.

More importantly, they define a novel function for this acceptor complex in mediating dead-end docking.

We define a novel distance measure excess gene leaf count (XL) between individual couplets.

Here, we define a novel role for vertebrate Llgl1 in regulating Yap stability in cardiomyocytes, which impacts heart development.

In conclusion, our study is the first to define a novel and crucial function of Ipc1 in fungal pathogenesis.

These results define a novel biochemical function for SSBPs in regulating the abundance of LIM domain and LIM domain-binding proteins.

Our results define a novel role for LMO2 in directly promoting DNA synthesis and G1-S progression.

In this study, we define a novel pathway involving the oncogenic transcription factor GLI2 modulating IgM secretion by WM malignant cells.

These studies define a novel IL-1a-TSLP-mediated crosstalk between tumor-infiltrating myeloid cells and tumor cells in the control of metastatic breast cancer.

Our goal is to study the underlying mechanism and define a novel signaling pathway controlled by OGDHL modulating pancreatic cancer progression.