Fecal excretion was the primary route of elimination of drug- derivedradioactivity in animals and humans.
2
On oral dosing to rats, ritonavir was found to increase the exposure of lopinavir- derivedradioactivity 13-fold.
3
The in vivo radiolabeled studies in preclinical species and human volunteers provide the total fate of the drug- derivedradioactivity including the relative abundance of metabolites.