However, CT-guided CNB requires further development for the accurate diagnosis of well- differentiated adenocarcinomas.

Only 50% of patients with well- differentiated adenocarcinomas were definitely diagnosed with CT-guided CNB.

In addition, this chromosomal arm was lost more frequently in poorly differentiated , compared to well differentiated adenocarcinomas.

We found that SGLT2 is expressed early in lung tumorigenesis and is found specifically in premalignant lesions and well- differentiated adenocarcinomas.

The cytoplasmic type was common in well- differentiated adenocarcinomas, and membranous or reduced expression was frequently seen in moderately- or poorly-differentiated adenocarcinomas.

In the periphery of the metastatic lesion, residual well to moderately differentiated adenocarcinomas were observed, and in the center, only necrotic tissue was seen.