Meanings of downstream signalling in English

Correlative studies were conducted to investigate the effect of erlotinib on downstream signalling.

How this ligand-receptor pair regulates the downstream signalling cascades in this context remains poorly understood.

The explanation for such contradictory outcomes may lay in how and which downstream signalling pathways are activated and drive disease.

Binding of insulin to the dimeric ECD triggers auto-phosphorylation of the tyrosine kinase domain and subsequent activation of downstream signalling molecules.

Responses to ADRβ2 agonists depend on effective downstream signalling following ADRβ2 activation and also on receptor regulation.

ATM protein activation as well as ATM pS1981 foci formation were defective and downstream signalling determined by Ser15 phosphorylation on p53 was reduced.