Correlative studies were conducted to investigate the effect of erlotinib on downstreamsignalling.
2
How this ligand-receptor pair regulates the downstreamsignalling cascades in this context remains poorly understood.
3
The explanation for such contradictory outcomes may lay in how and which downstreamsignalling pathways are activated and drive disease.
4
Binding of insulin to the dimeric ECD triggers auto-phosphorylation of the tyrosine kinase domain and subsequent activation of downstreamsignalling molecules.
5
Responses to ADRβ2 agonists depend on effective downstreamsignalling following ADRβ2 activation and also on receptor regulation.
6
ATM protein activation as well as ATM pS1981 foci formation were defective and downstreamsignalling determined by Ser15 phosphorylation on p53 was reduced.