1
We investigated whether endogenous glucose production is lower in Snell dwarf mice during feeding.
2
Pyruvate carboxylase ASO reduced plasma glucose concentrations and the rate of endogenous glucose production in vivo.
3
Collectively these phenomena may be viewed as an orchestrated feedback loop, controlling endogenous glucose production, lipolysis and ketogenesis.
4
The pathophysiological hallmarks of type 2 diabetes mellitus consist of insulin resistance, pancreatic beta-cell dysfunction, and increased endogenous glucose production.
5
Lipid accumulation in the liver induces hepatic insulin resistance, which leads to impaired suppression of endogenous glucose production after feeding.
6
In conclusion, insulin sensitivity is reduced 6 months after KTx and characterized mainly by impaired suppression of the endogenous glucose production.
7
In view of cancer cell dependence on glucose for energy, low endogenous glucose production may provide Snell dwarf mice with resistance to cancer.
8
Methods: A physiologically based two-compartment system model that accounts for time-varying insulin sensitivity, time-varying endogenous glucose removal, and two saturation kinetics mechanisms is developed.
9
Inhibition of endogenous glucose production by glucose injection was enhanced in 12 to 14 month-old female Snell dwarf mice.
10
Thus, we hypothesize that lower endogenous glucose production during feeding and fasting reduces cancer cell glucose utilization providing Snell dwarf mice with resistance to cancer.
11
Endogenous glucose production and glucose disappearance did not differ significantly among groups.
12
Endogenous glucose production during fasting is reduced in Snell dwarf mice compared to fasting control mice.
13
Endogenous glucose production and glucose disappearance rate (N = 6) were measured in a subgroup of patients with corresponding controls.
14
Endogenous glucose production and whole body protein metabolism were assessed by isotope dilution techniques using tritiated glucose and stable phenylalanine and tyrosine isotopes, respectively.
15
Endogenous glucose production (EGP) was elevated in CTR compared to HP after TNF-a administration, whereas insulin sensitivity remained similarly unaffected in both groups.
