Conclusions: The contrast patterns of well-differentiated and moderately to poorly differentiated hepatocellular carcinomas were quite different on contrast- enhanced sonography.

We addressed the question whether contrast- enhanced sonography allows for intervention of hepatic lesions impossible to detect on conventional B-mode imaging.

Objectives: The purpose of this study was to determine whether contrast- enhanced sonography can be used to differentiate histopathologic grades of hepatocellular carcinoma.