DJ-1 is an oncogene and also causative gene for familialParkinson's disease.
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DJ-1 is an oncogene and also a causative gene for familialParkinson disease.
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Recently, a mutation of DJ-1 was found to be responsible for familialParkinson's disease.
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To screen the susceptibility genes in Chinese pedigrees with early-onset familialParkinson's disease (FPD).
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Neither the natively unfolded nor the partially folded intermediate conformations are affected by the familialParkinson's disease point mutations.
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Previous genetic analysis of the familialParkinson's disease Contursi kindred led to the identification of an Ala53Thr pathogenic mutation in the alpha-synuclein gene.
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We have established that the frequency of LRRK2 mutations in a series of 118 cases of familialParkinson's disease is 5.1%.
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PMID: 16272164 We have established that the frequency of LRRK2 mutations in a series of 118 cases of familialParkinson's disease is 5.1%.