Meanings of functional inactivation in English

Protein structure analysis indicates that all three mutations lead to functional inactivation of the protein.

Thus, we next investigated if functional inactivation of Cav-1 gene expression leads to mammary tumorigenesis in vivo.

We show that siRNA expression mediated by this vector causes efficient and specific down-regulation of gene expression, resulting in functional inactivation of the targeted genes.

We postulate an alternative mechanism of retinoblastoma tumorigenesis that involves functional inactivation of retinoblastoma protein locally in the face of an intact retinoblastoma gene locus.

Increased HIV-1 replication also was observed in CEM cells with diminished CD43 expression secondary to functional inactivation of a single CD43 allele.

Interventions: Functional inactivation of the central nucleus of the amygdala with TTX.