Objective: Stimulation of the central cholinergic system results in generalized epileptic seizures.

One patient with mutation subsequently developed paroxysmal dyskinesia, as well as generalized epileptic seizures.

The most common type of epileptic seizure was generalized epileptic seizures (75 %).

The results suggest that M1 muscarinic receptors are preferentially involved in the initiation of generalized epileptic seizures in the basal diencephalon of the rat.