Inhibition of soluble TNFa using a dominant-negative strategy effectively promotes RGC survival.

Retinas were obtained and processed for RGC counting with a confocal microscope.

Caspase-2-dependent cell death is important and evidenced in models of RGC degeneration.

Conclusion: The elevation in IOP precedes the loss of RGCs by several months.

RGCs cell loss occurs particularly in peripheral regions of the retina.