Multivariable linear mixed-effects models were used to analyze rate of change in globalcognition.
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Cardiorespiratory fitness is associated with globalcognition, executive function, attention and information processing speed.
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For this analysis, the primary outcome was globalcognition Z-score at 12-weeks adjusted for baseline.
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BDNF and PAI-1 were not associated with globalcognition.
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Behavior change, globalcognition, executive function, and magnetic resonance imaging brain atrophy were also evaluated.
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Only abnormal P-wave terminal force in lead V1 was associated with greater decline in globalcognition.
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In both age groups, severe brain arteriolosclerosis was associated with worse performances on globalcognition tests.
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The most novel finding shows that negative affect is related to decreased globalcognition and visuospatial ability.
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Cognitive function was assessed at 3-y intervals on the basis of a composite measure of globalcognition.
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Deep WML burden and PVWML burden were associated with reduced globalcognition in AD but not in nondemented aging.
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A PVWML x AD status interaction for globalcognition suggests that the relationship between PVWMLs and cognition is modified by AD.
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Conclusions: Ketone infusion specifically improved working memory performance in patients with type 2 diabetes in the absence of changes in globalcognition.
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Antidepressant treatments that preserve or enhance globalcognition in addition to relieving core depressive symptoms may lead to the best functional outcomes.
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The clinical evaluations included detailed testing of cognitive function from which previously established composite measures of globalcognition and specific cognitive functions were derived.
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Conclusions: In a population cohort of older women, lifetime HRT exposure was associated with improved globalcognition and attenuated decline over a 3-year interval.
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Total WMH volume directly correlated with measures of hypertension and inversely correlated with measures of globalcognition, particularly in executive functioning, and psychomotor speed.