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The new metabolites fall into two categories, glucuronides and phenylbutyrate beta-oxidation side products.
2
Plasma concentrations of morphine and its glucuronides were not significantly changed by quinidine pretreatment.
3
The method was applied in profiling of targeted and nontargeted steroids and steroid glucuronides during pregnancy.
4
The results suggest that steroids and especially steroid glucuronides may provide a valuable diagnostic tool to follow the course of pregnancy.
5
The method provides high sensitivity and fast analysis, as both steroids and their glucuronides can be analyzed directly without hydrolysis or complex sample preparation.
6
This new analytical method should be useful for quantifying cannabinoids in whole blood and further investigating cannabinoid glucuronides as markers of recent cannabis intake.
7
It was also found that RBF was capable of binding even conjugates containing mutagens such as glucuronides and sulfates, as well as metabolites in urine.
8
The use of deuterated internal standards (IS) for each analyte was necessary to compensate for ME and was essential in the determination of glucuronides.
9
CYP2D6 genotypes predicting ultrarapid metabolism resulted in about 50% higher plasma concentrations of morphine and its glucuronides compared with the EM.