Meanings of hereditary cancers in English

High-throughput gene sequencing has identified various genetic variants as the culprits for some common hereditary cancers.

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer.

Defects in mismatch repair (MMR) genes have been involved in several types of sporadic and hereditary cancers.

Other hereditary cancers are seen less frequently, but genetic testing has increased for many other site-specific cancers and complex syndromes.

Conclusions: These results suggest that most synchronous primary endometrial ovarian cancers are not hereditary cancers caused by germ line mutations but rather sporadic cancers.

Hereditary cancers derive from gene defects that often compromise DNA repair.