Ischemia or high lactate probably do not contribute to fatigue in this state.

In most regions with high lactate levels, infarction subsequently occurred.

Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.

The decreased levels of plasma glucose and myocardial glucogen, but the high lactate in blood and myocardium showed myocardial metabolic disturbance.

Patients with a high lactate dehydrogenase level had a lower ORR of 33% and a short TTP of only 6 months.