1
However, the functional equivalency between human ESC-CMs and iPSC-CMs for cardiac regenerative therapy has not been demonstrated.
2
Furthermore, the effects of BV6 on human ESCs and mouse endometriosis-like lesions may differ between the species.
3
To examine the role of telomerase in human ESC self-renewal and differentiation, we modulated the expression of TERT.
4
Surprisingly, in contrast to findings in mouse, deletion of DNMT1 resulted in rapid cell death in human ESCs.
5
Human ESCs are differentiated without morphogens into neuroepithelial cells that form neural tube-like rosettes in the first 2 weeks.
6
Expression of novel transcripts from this transcriptionally active region confirmed the existence of NANOG alternative splicing in human ESCs.
7
Importantly, these Cnot genes are also necessary for the maintenance of human ESCs, and silencing them mainly lead to TE and primitive endoderm differentiation.
8
Additionally two other independently isolated and cultured human ESC lines as well as their differentiated derivatives were monitored for differential expression of selected proteins.
9
One major hurdle is related to problems in generating large and defined populations of the desired types of neurons from human ESCs (hESCs).
10
While this paper investigated hepatic differentiation of mouse ESCs, our findings and stem cell culture approaches are likely to be relevant for human ESC cultivation.
11
Iterative chemical screening identified a combination of five kinase inhibitors that induces and maintains OCT4 distal enhancer activity when applied directly to conventional human ESCs.
12
Comparison with previously reported naive human ESCs indicates that our conditions capture a distinct pluripotent state in humans that closely resembles that of mouse ESCs.
13
After transplantation into mouse neonatal brain, human ESC-derived cortical neurons integrated robustly and established specific axonal projections and dendritic patterns corresponding to native cortical neurons.