1
Tree shrew PDAC possesses the main histological and molecular features of human PDAC.
2
Consistent with this hypothesis, active macropinocytosis is observed in primary human PDAC specimens.
3
The clinical relevance of our findings was validated by analyzing human PDAC specimens.
4
When human PDAC cells are injected into immunodeficient mice, they generate advanced-stage cancer.
5
Materials and methods: SW1990 human PDAC were subcutaneously implanted in 20 nude mice.
6
Time-lapse microscopy was used to observe invasion in organoids from 25 surgically resected human PDAC samples in collagen I.
7
Results: There was a striking inverse correlation between reduced expression of VDR and increased expression of FOXM1 in human PDAC cells and tissues.
8
In this study, human PDAC genome analyses revealed frequent deletion of the PTEN gene as well as loss of expression in primary tumor specimens.
9
Increased levels of CXCR3 and CCR7 in human PDAC specimens were associated with increased frequency of cancer-associated pain, determined from patient questionnaires.