1
Together, these observations implicate novel elements of the BCR signal transduction as potential therapeutic targets.
2
Newly identified genes implicate novel mechanisms such as rod-and-cone bipolar synaptic neurotransmission, anterior-segment morphology and angiogenesis.
3
Expression array technologies have as yet not been employed, but can be expected to implicate novel candidates and neurobiological pathways.
4
Our findings thus characterize the mutational landscapes of PHNET and implicate novel gene mutations linked to PHNET pathogenesis and potential therapeutic targets.