Including C-reactive protein and fibrinogen with standard Framingham risk factors did not improve discrimination of the model.

Several clinical studies demonstrate the inverse relationship between plasma adiponectin levels and several inflammatory markers including C-reactive protein.

Xoma said the trials also showed that 052 improved levels of other diabetes and inflammation markers, including C-reactive protein.

It is well accepted that circulating biomarkers, including C-reactive protein and interleukin-6, reliably predict major cardiovascular events, including myocardial infarction or death.

However, low levels of IGF-I and IGFBP-3 were associated with increased levels of markers of inflammation including C-reactive protein and interleukin-6 levels.