Meanings of induce neurodegeneration in English

The currently favored hypothesis is that Aβ aggregates to toxic forms that induce neurodegeneration.

PolyQ expansion may induce neurodegeneration by impairing proteostasis, but protein aggregation and toxicity tend to confound conventional measurements of protein stability.

Summary: Aβ aggregation is the key initial trigger of Alzheimer's disease pathologic changes and interacts with tau to exacerbate age-related tauopathy and induce neurodegeneration.

This IN Tat model of neuroinflammation may be useful to study HIV-1- induced neurodegeneration.

VEGF is up-regulated in neurons and glial cells after epileptic seizures and counteracts seizure- induced neurodegeneration.

Taken together, our data suggest a CNS-specific effect of L-type voltage-gated calcium channel blockade to inflammation- induced neurodegeneration.

Our results provide evidence that pentraxin 3 is synthesized in brain after seizures and may exert a protective role in seizure- induced neurodegeneration.

Together, these findings define HDAC6 as a potential nontoxic therapeutic target for ameliorating CNS injury characterized by oxidative stress- induced neurodegeneration and insufficient axonal regeneration.