That humans are emotionally fragile, perennially gullible, hopelessly ignorant masters of an insignificantly small speck in the cosmos.

Plato seemed insignificantly small and weak, and she felt miserably unable to cope with any difficult or untoward situation.

The farm-holding was insignificantly small, as was the case in those parts; but my host uttered no word of its insufficiency.

And while to the less mindful among us moss may seem insignificantly small, no Zen garden is complete without its moss-covered rock or stone lanterns.