Meanings of intracellular accumulation in English

Thus, intracellular accumulation of heme has not been observed in mammalian cells to date.

The intracellular accumulation of such di-tripeptides may be important in enterocytes becoming immune accessory cells.

Greater intracellular accumulation of TByA in PT cells may play a role in the enhanced cytotoxicity.

Azithromycin is a widely used macrolide antibiotic with sustained and high tissue penetration and intracellular accumulation.

These decreases were not attributable to the intracellular accumulation of TSH or its free beta subunit.

Comprehensive mechanistic exploration revealed dramatic intracellular accumulation of TKIs which closely correlated with induction of apoptosis.

Before antibiotic challenge, some cells were preincubated with amikacin for 3 days to allow intracellular accumulation of drug.

The protective effect of ionic solutes relies on the intracellular accumulation of compatible solutes as a response to the osmotic stress.

Macrophage sortilin causes internalization of LDL and probably a reduction in cholesterol efflux, resulting in the intracellular accumulation of excessive lipids.

Our cellular uptake experiments reveal that q-NTD accumulated most effectively within cancer cells while NTD shows the lowest intracellular accumulation concentration.

Biochemical, pharmacological, and genetic inhibition of this signaling pathway result in a block in hemoglobin production and concomitant intracellular accumulation of protoporphyrin intermediates.

The intracellular accumulation of TFV was reduced by the addition of endocytosis inhibitors, and this resulted in the loss of TFV antiviral activity.

Mechanisms supposed to be involved in these conditions include the Randle cycle, intracellular accumulation of lipid metabolites, inflammation and mitochondrial dysfunction or mitochondrial stress.

A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells.

As a genetic reporter, NanoLuc may be configured for high sensitivity or for response dynamics by appending a degradation sequence to reduce intracellular accumulation.

We propose a model for the intracellular accumulation of maytansinoids in which molecules of the compounds diffuse into a cell and associate with tubulin.