Rmrp mutation inhibits the intramembranousossification of skull bones and promotes vertebrae ossification.
2
Similar expression patterns were observed at sites of intramembranousossification.
3
Premature fusion of cranial sutures, caused by deficiency in intramembranousossification, occurs at early postnatal stages.
4
These results demonstrate that fibromodulin is developmentally expressed in cartilage and bone cells during endochondral and intramembranousossification.
5
Intramembranousossification is a complex multi-step process which relies on extensive interactions among bone cells and surrounding tissues.