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1 Background: Innate immunity is essential in defending against invading pathogens in invertebrates.
2 Plants employ a two-tier innate immune system to defend against invading pathogens .
3 Neutrophils are responsible for the first line of defense against invading pathogens .
4 Neutrophils migrate to infected mucosal sites that they protect against invading pathogens .
5 In exchange, the commensal microbes provide critical protection against invading pathogens .
6 This diffusible oxidant plays a critical role in the destruction of invading pathogens .
7 Autophagy is an important host defense mechanism which targets invading pathogens .
8 Activation of these molecules leads to inflammatory responses which help clearance of invading pathogens .
9 Autophagy protects cellular homeostasis by capturing cytosolic components and invading pathogens for lysosomal degradation.
10 The primary function of the immune system is to protect the organism from invading pathogens .
11 Phagocytosis of invading pathogens and their subsequent clearance in lysosomes is important for organismal fitness.
12 Macrophages produce genotoxic agents, such as reactive oxygen and nitrogen species, that kill invading pathogens .
13 However, one of the most effective methods of defense against invading pathogens and parasites is itch.
14 Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens .
15 TLRs are critical innate immune sensors in the induction of proinflammatory cytokines to eliminate invading pathogens .
16 The intestinal immune system can respond to invading pathogens yet maintain immune tolerance to self-antigens and microbiota.
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