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Meanings of lead to abrogation in English

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Usage of lead to abrogation in English
1
Conclusions: We identified a natural compound that potently inhibits V-ATPase and thereby lysosomal acidification in osteoclasts, which leads to abrogation of bone resorption.
Pubmed
2
We find that both genetic and pharmacological inhibition of CDK8 and its homologous twin kinase CDK19 leads to abrogation of BMP-induced EMT.
Pubmed