The next week they lost quarterback Nate Sudfield to a shoulder injury and it's been all downhill from there.

Tennessee not only fell to previously winless Jacksonville, but may have lost quarterback Jake Locker for the season with a foot injury.

The Browns, meanwhile, lost quarterback Josh McCown (concussion) when he tried scrambling for a touchdown on their first offensive series.

The Colts also lost quarterback Matt Hasselbeck briefly in the fourth quarter and fell to 3-4 at home.

The Eagles (6-9) lost quarterback Carson Wentz briefly in the third quarter when they led 21-16.

The New Orleans Saints have lost five of their last six games and may have lost quarterback Drew Brees for the rest of the season.

FIU (8-5) lost quarterback Alex McGough on the opening series to a fractured collarbone and struggled to move the ball consistently after that.

Already shorthanded on offense without star running back Adrian Peterson, the Vikings (1-2) lost quarterback Matt Cassel to a toe injury in the first quarter.