Meanings of low bioavailability in English

ABZ has limited effectiveness due to its poor water solubility and consequent low bioavailability.

Previously reported FimH antagonists exhibit good potency and efficacy, but low bioavailability and a short half-life in vivo.

Nicotine tartrate administered as either a liquid enema or as an oral solution had low bioavailability and was well tolerated.

However, its application as a radioprotectant is limited, at least in part, by its short plasma elimination half-life and low bioavailability.

PVP-K90-laden contact lenses can be used to overcome the limitations of eye drop solutions ( low bioavailability and frequent instillation).

A prodrug strategy was also investigated to address the problem of low aqueous solubility and low bioavailability of the antitumor agent CHM-1.

The development of nanocarriers for curcumin delivery is an attractive approach to overcome its low bioavailability and fast metabolism in the liver.

However, the clinical advancement of this promising molecule has been hindered by its poor water solubility, short biological half-life, and low bioavailability after oral administration.