Meanings of major bottleneck in English

In vaccine development, the identification of efficacious antigens forms the major bottleneck.

While previous studies have successfully automated feature curation, annotation remains a major bottleneck.

Bringing the construction industry online reduces the need for paperwork, traditionally a major bottleneck.

A major bottleneck of this goal is nucleic acid extraction.

Lower coal production and supply shortages have emerged as a major bottleneck in infrastructure sector.

The current major bottleneck is to model the conformational changes of the monomer backbone upon binding.

The absence of culture systems permissive for HCV replication has presented a major bottleneck to antiviral development.

Obtaining sequence-specific assignments remains a major bottleneck in solution NMR investigations of supramolecular structure, dynamics and interactions.

However, a major bottleneck still remains; the identification of conditions that give crystals that are suitable for structure determination.

However, as new automation methods emerge that enable high-throughput assembly, QC using these techniques has become a major bottleneck.

Results were reported back in early autumn, several months later, as identifying invertebrates caused a " major bottleneck".

Low efficacy of gene-based vaccines due to inefficient gene delivery and expression has been major bottleneck of their applications.

Background: A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins.

PMID: 28701143 However, as new automation methods emerge that enable high-throughput assembly, QC using these techniques has become a major bottleneck.

The paucity of enzymes that efficiently deconstruct plant polysaccharides represents a major bottleneck for industrial-scale conversion of cellulosic biomass into biofuels.

However, crossing endothelial and epithelial cell layers like the blood-brain barrier and the blood-intestinal barrier represents a major bottleneck for drug targeting.