Their choice puts themselves, and especially their children, at a major disadvantage.

If this happens occasionally, you might not consider this a major disadvantage.

But Abbott has a major disadvantage compared with the imaginary alien leader.

However, prolonged skin photosensitivity is a major disadvantage of this form of therapy.

But those digital proving grounds come with one major disadvantage: They just don't hurt enough.

The major disadvantage of the currently available stent grafts is their lack of mechanical flexibility.

What is the major disadvantage of any back up (especially tape method backup)?

Elm has a major disadvantage for the beginner.

It quickly became apparent that this was a major disadvantage when a suspected offender was being sought.

This can be a major disadvantage, especially for active mutual fund investors who keep a keen eye on movements.

That was a major disadvantage.

The major disadvantage of hierarchical clustering in fMRI data analysis is that an appropriate clustering threshold needs to be specified.

The immune responses of individual mice within a group were highly variable, which constitutes a major disadvantage of this model.

The major disadvantage of current artificial devices lies in the fact that they cannot grow, remodel, or repair in vivo.

The major disadvantage of the GelPort was its price, which was about a third more than that of the first-generation devices.

The major disadvantage associated with the use of curcumin, however, is its low systemic bioavailability due to its poor aqueous solubility.