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1
Loss of apico-basal polarity often results in a
malignant
phenotype
in epithelial tissues.
2
Proteases are linked to the
malignant
phenotype
of different solid tumors.
3
A previous study demonstrated that TRAF6 promotes the
malignant
phenotype
of melanoma cells.
4
Various signalling pathways can confer the
malignant
phenotype
to a cell.
5
Therefore, it plays novel roles in tumor
malignant
phenotype
,
such as invasion and metastasis.
6
However, direct evidence that PDCD4 inhibits
malignant
phenotype
of human cancer cells is limited.
7
HuR knockdown attenuates the
malignant
phenotype
of oral cancer cells.
8
Non-receptor tyrosine kinase c-Src contributes to the transformation to a
malignant
phenotype
in various cancers.
9
Little is known on the molecular mechanisms leading to the
malignant
phenotype
in adrenocortical tumors.
10
These cells exerted a
malignant
phenotype
with regard to their in vitro and in vivo characteristics.
11
Further, they suggested that bcl-2 is associated with a more progressed
malignant
phenotype
in these tumors.
12
This suggests that the E6 gene product may be important in the maintenance of the
malignant
phenotype
.
13
We proposed that the activation of telomere maintenance pathways confers a perpetual
malignant
phenotype
to these tumors.
14
Expressions of Disabled-2 and Axin were concurrently reduced and correlated with the
malignant
phenotype
of lung cancers.
15
Aberrant DNA methylation contributes to the
malignant
phenotype
in virtually all types of cancer, including myeloid leukemia.
16
These findings suggest that progression of the tax-transgenic cells toward a more
malignant
phenotype
might involve c-myc deregulation.
malignant
phenotype
malignant