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1
In particular, hypermethylation of CpG islands is a signature of
malignant
progression
.
2
Cancer cell plasticity facilitates the development of therapy resistance and
malignant
progression
.
3
QPCR showed changes in gene expression consistent with the vascular changes and
malignant
progression
.
4
Unusually, the mass demonstrated
malignant
progression
leading to death at 20 months of age.
5
Defects in DNA damage responses may underlie genetic instability and
malignant
progression
in melanoma.
6
Persistent STAT3 signaling contributes to
malignant
progression
in many diverse types of human cancer.
7
These results suggest that v-fos oncogene functions in the transfected cells and causes
malignant
progression
.
8
The molecular events driving IDP development and genomic features of
malignant
progression
are poorly understood.
9
In this review, we present potential biomarkers for the prediction of
malignant
progression
in BE.
10
It has been suggested that an inverse correlation exists between cystatin A and
malignant
progression
.
11
Accumulation of tumor-associated macrophages (TAM) correlates with
malignant
progression
,
immune suppression, and poor prognosis.
12
WNT5A has been identified as an important ligand in the
malignant
progression
of a number of tumours.
13
Palbociclib treatment of mice with MCFDCIS tumors inhibited their
malignant
progression
and reduced proliferation of invasive lesions.
14
To monitor
malignant
progression
,
serial micro CT scans with respiratory gating (no contrast) was performed.
15
Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the
malignant
progression
.
16
Lack of mitotic regulation induces aneuploidy in cancer cells acting thereafter as a driving force for
malignant
progression
.
malignant
progression
malignant