Meanings of mechanical unloading in English

The mechanism for the decrease in cardiomyocyte size with mechanical unloading is unknown.

For mechanical unloading, we also heterotopically transplanted rat or mouse hearts for 1 week.

Myostatin may affect cardiac hypertrophy and may mediate regression of cellular hypertrophy after mechanical unloading.

In summary, mechanical unloading increases c-myc activity and c-myc-regulated gene expression in the rat heart.

We hypothesized that mechanical unloading would alter the UPR in patients with advanced heart failure (HF).

These results suggest that autophagy and FoxO1 play an essential role in mediating regression of cardiac hypertrophy during mechanical unloading.

Context: Animal models and human studies suggest that osteocytes regulate the skeleton's response to mechanical unloading in part by an increase in sclerostin.

Conclusions: These results indicate that the failing human heart increases expression of leptin and its receptor and that mechanical unloading downregulates this increase.

Regression of cardiac hypertrophy and improvement of the functional capacity of failing hearts have reportedly been achieved by mechanical unloading in cardiac work.

UPR activation and apoptosis are reduced after mechanical unloading, which may be mediated by the improvement of Ca(2+) handling in patients with advanced HF.

Mechanical unloading of the failing human heart significantly increased calpain 2 gene expression.

Mechanical unloading of the rat heart increases both protein synthesis and protein degradation.

Methods and results: Mechanical unloading, by heterotopic transplantation, decreased heart weight and cardiomyocyte cross-sectional area in wild type mouse hearts.

Background: Mechanical unloading of the failing human heart induces profound cardiac changes resulting in the reversal of a distorted structure and function.

Mechanical unloading with a left ventricular assist device (LVAD) relieves pressure-volume overload and promotes reverse remodeling of the failing myocardium.