Meanings of minor groove in English

We applied the approach to study minor groove binding of diamidines and pyrrole-imidazole polyamides.

By comparison, Liquori's minor groove model appears to be less stable than the major groove model.

Therefore, we speculate that new imidazopyridines induce their pharmacological effect by targeting the minor groove of DNA.

These internal loop triples contain several examples of a frequently found motif, the minor groove AGC triple.

A continuum of structures may be possible where intercalation and classical minor groove binding are limiting structures.

We conclude that efficient topoisomerase activity is required for the active dissociation of DNA minor groove-ligand complexes.

Simulated A-, I-, and AI-tracts show almost identical structures, with high propeller twist and minor groove narrowing.

Mutational, footprinting and interference studies indicate predominant interactions of I-TevI across the minor groove and phosphate backbone of the DNA.

The unpaired pyrimidine bases lie in the minor groove of one of the helices and are partly exposed to solvent.

The small molecules that bind to DNA minor groove are considered as potential therapeutic agents to fight against many human diseases.

The biological effects of a number of DNA ligands which interact with the minor groove of B-form DNA (e.g.

The histidine residues of the AAA+ domains insert into a narrow minor groove region with enhanced negative electrostatic potential.

These interactions arise from a shortened minor groove caused by an AT-rich stretch, suggesting adaptability of ZF arrays to sequence variations.

This domain binds in the minor groove of DNA inducing a sharp bend and also preferentially binds to certain distorted DNA structures.

Tallimustine binds to the minor groove of DNA where it alkylates the N3 position of adenine and may interfere with gene transcription.

A duplex real-time RT-PCR assay using minor groove binder (MGB) probes for differential detection of the two US PRRSV isolates was developed.