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A case of osteosarcoma arising from a multipleexostoses lesion is presented.
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Objective: To identify the gene causing hereditary multipleexostoses in a Chinese pedigree.
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Approximately 10 per cent of the subjects had no family history of multipleexostoses.
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The camel was affected with rickets and the aurochs had multipleexostoses or bony tumors.
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Hartmann shows two cases of multipleexostoses, both in males, and universally distributed over the body.
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We have carried out a linkage analysis on 11 families segregating gene(s) for hereditary multipleexostoses (EXT).
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The osteosarcoma, complicated by multipleexostoses, had a very poor prognosis because it was resistant to various anticancer agents.
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Objective: To investigate further the genetic basis of hereditary multipleexostoses (EXT) and provide useful information for gene diagnosis of the disease.
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An X;8 translocation was identified in a 27-year-old female patient manifesting multipleexostoses and autism accompanied by mental retardation and epilepsy.
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Methods: We investigated LEMD3 and EXT1 in the three-generation family from Poland, with 5 patients affected with osteopoikilosis and one child affected with multipleexostoses.