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1 HTZ1, a regulator of chromatin structure and gene expression, represents a class of genes implicated in mutational robustness .
2 We suggest that regulatory feedback may be an important element of the network architectures that confer mutational robustness across biology.
3 Theory predicts that the strength of direct selection for mutational robustness is at most the magnitude of the rate of deleterious mutation.
4 Mutational robustness describes the extent to which a phenotype remains unchanged in the face of mutations.
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