We used a leaky stochastic accumulator to model the neu …

Amplification and overexpression of the neu gene have been found in several human adenocarcinomas.

Together these studies indicate that p185neu expression is a common feature of human lung tumors.

Down-modulation of the normal cell-surface neu protein was inefficient.

Survival of animals was significantly prolonged after immunization with vaccines encoding neu together with the costimulatory molecules.