Conclusions: This large study identified a new locus for depression.

To map this new locus we performed genetic linkage analysis with microsatellite markers in a four-generation pedigree.

This defines a new locus associated with prostate cancer susceptibility on 8q24.

We investigated that problem by analytically computing the expected lod score per meiosis in which the new locus is informative and phase known.

Here we report the identification of a new locus for an autosomal dominant anterior polar cataract on the short arm of chromosome 17.

It led to the identification of a new locus on chromosome 6q22-q24 spanning 6.4 cM between D6S1620 and D6S975.

Conclusion: The mutation rate of TH gene in Chinese patients with AR-DRD is low, hence suggesting the genetic heterogeneity and a new locus for AR-DRD.

One of these mutants has been mapped to chromosome X, 31 cM distal to SUP4, and defines a new locus designated STE18.