These nonclassical monocytes showed a more activated phenotype in pregnant ATP-infused rats only.

ATP infusion increased the percentage of nonclassical monocytes in pregnant rats even further but not in nonpregnant rats.

Compared with controls, the frequency of nonclassical monocytes was significantly increased in patients with active ITP but decreased after complete remission.

In rats, we also found lower percentages of classical monocytes and higher percentages of nonclassical monocytes in pregnant versus nonpregnant rats.