Freshly and persistently infected cells were transfected with siRNAs targeting various sites in the HAV nonstructural genes.

Conclusions: Hepatitis C virus nonstructural genes induce an increased expression of transforming growth factor beta1 and other profibrogenic factors in infected hepatocytes.

USA 85, 5997-6001), WEE virus acquired its nonstructural genes from an EEE-like ancestor during recombination.